Serine is one of the non-essential amino acids that make up protein. It is synthesized in the body and plays roles in protein, fatty acid, genetic code carriers (DNA and RNA) synthesis, and muscle build up. Serine is a constituent in the brain and protective covers of nerves; therefore, it is an important amino acid for the proper functioning of the brain and nervous system. Serine boosts healthy immune system by aiding the production of antibodies.

Symptoms Linked to Serine Deficiency:

Serine deficiency symptoms include slow or delayed cognitive and physical skills (psychomotor retardation), seizures and microcephaly. Microcephaly refers to health condition in which the head size is smaller than normal and is caused by underdevelopment of the brain.

Health Problems Associated to Serine Deficiency: 

  • ADHD – Administration of phosphatidylserine with omega 3 fatty acids improved ADHD symptoms (attention scores) significantly better than omega 3 fatty acids alone, suggesting a synergistic effect. Phosphatidylserine increases dopamine levels.
  • Anxiety – Exerts a calming effect by buffering the adrenal response to physical or emotional stress. Lowered anxiety scores of patients with post-traumatic stress disorder.
  • Depression – Regulates brain chemistry. Involved in NMDA receptor function. Acts as a neurotransmitter. Low levels correlate with severity of depression.
  • Fatigue – Counteracts the overproduction of fatigue-causing stress hormones.
  • Fibromyalgia – Blood levels of this amino acid are much lower in fibromyalgia patients.
  • Methylation – Important methyl donor especially in the case of Folate deficiency.
  • Sports Nutrition – Keeps an athlete’s hormone profile healthy by buffering post-workout cortisol levels which can cause excess muscle breakdown. May increase aerobic capacity.

How to Acquire Serine:

  • Egg, raw, fresh
  • Nuts – almonds, walnuts (English)
  • Flax seed, raw
  • Organ Meats such as liver & kidneys
  • Hummus
  • Milk, goat, fluid
  • Asparagus

Clinical Updates on Serine